3D Character Variations
From Homestar Runner Wiki
Although made mostly in Flash, and usually 2-dimensional, the characters of homestarrunner.com have had 3-dimensional variations as well. The biggest case (so far) is Strong Bad's Cool Game for Attractive People, where all characters that appear are in 3D.
SBCG4AP Variations
DVD Menu Variations
Other 3D Variations
*These 3D variations were likely made in Flash, rather than a 3D-rendering program.