From Homestar Runner Wiki
Melissa "Missy" Palmer is a childhood friend of The Brothers Chaps, and Mike Chapman's wife (as of February 28, 2004). She provides the voice of Marzipan (except for Tis True, Pom Pom, Tis True), and her 20X6 and Old-Timey counterparts, and on one occasion voiced Homestar Runner with a "spit bubble" stuck in his throat. She also co-wrote The Luau.
She works in the film industry as a producer and assistant director. It was reported in the Flashforward 2006 Seattle - 28 Feb 2006 interview that she was pregnant. She and Mike have since had a daughter.