Free Petry Dish, USA Character Variations

Homestarmecium appears as to be a bacterium or other prokaryote (possibly a ciliate), because he is drawn without a nucleus and replicates via binary fission. He is the same general shape as Homestar, but without legs. He is a throbbing blue blob with bubbles and colored shapes floating inside of him, two of which make up his eyes. He has short strands of hair on his head. He is plagued by an embarassing rear-end problem for which Bubsamecium provides a soothing cream. He can instantly replicate himself to scare off an invading Strongbadiophage. He can also produce multiple feet or pseudopodia from his body.

Bubsamecium is the proprietor of Bub5amecium's Protozoa Stand and appears to be shaped like the typical perception of an amoeba, with Bubs's eyes and toothy mouth floating within the shifting blue mass.

Strongbadiophage is a malevolent virus. His head is more polygonal than his regular counterpart, and he has a long, yellow, almost spiky neck, with a short cylindrical blue base from which six gray, spindly, spider-like legs emerge. He appears to be the main antagonist of Homestarmecium, though he is frightened at the idea of more than one of him. He is modeled after the Enterobacteria phage T4. Ironically, his name means "one that eats Strong Bad" or "one that eats Strong Badia".